Secondary structure prediction for aligned RNA sequences.
نویسندگان
چکیده
Most functional RNA molecules have characteristic secondary structures that are highly conserved in evolution. Here we present a method for computing the consensus structure of a set aligned RNA sequences taking into account both thermodynamic stability and sequence covariation. Comparison with phylogenetic structures of rRNAs shows that a reliability of prediction of more than 80% is achieved for only five related sequences. As an application we show that the Early Noduline mRNA contains significant secondary structure that is supported by sequence covariation.
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عنوان ژورنال:
- Journal of molecular biology
دوره 319 5 شماره
صفحات -
تاریخ انتشار 2002